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My company shares my
passion for helping to improve human health around the world."
"This is My MedImmune."
Those who join MedImmune feel a sense of ownership about their future. They thrive with a recognized leader in the biotechnology industry and the wholly-owned subsidiary of AstraZeneca plc.
Here, you will join passionate professionals who advance science, technology and medicine to develop products designed to help people live better lives. You will excel in an environment characterized by respect, integrity and growth opportunities…that encourages both individual contribution and collaborative entrepreneurial thinking. Our products and/or product candidates are designed to address areas of need in infection, oncology, respiratory disease and inflammation, cardiovascular/gastrointestinal disease and neuroscience. Explore a MedImmune career as we strive to better more lives, more often, around the world.
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Title: Scientist I/II
Location: MD, Gaithersburg - Corporate Headquarters
Req: 02103
Position Summary:
Major Duties and Responsibilities (including supervising others):
Responsible for planning and executing purification process development and optimization for complex novel molecules such as protein-drug conjugates, bi-specific antibodies, fusion proteins, and proteins expressed in E.coli that require re-folding. Candidate is expected to lead or participate in solving challenging protein purification problems such as aggregate removal, protein self association, and glycoform separation. Provides technical expertise in process scale-up and technology transfer to cGMP clinical and commercial manufacturing. Coordinates closely with the analytical biochemistry group and other research and development groups in order to meet project timelines and company goals. Additional job expectations include analyzing and interpreting analytical and process data and understanding the overall project implications of process changes and decisions. Expected to identify new technology and conduct necessary experiments for implementation. Author/reviewer in the preparation of regulatory documents such as INDs, IMPDs, and BLAs. Supervise personnel in the laboratory.
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Special Skills/Abilities:
• Theoretical knowledge and practical experience in biotherapeutic purification process development and scale up
• Experience developing protein purification processes for non-Mab molecules such as bispecific antibodies, fusion proteins, and PEGylated proteins.
• Experience solving challenging protein purification problems such as aggregate removal, protein self association, and glycoform separation.
• Experience with protein modification and conjugation chemistry a plus
• Ability to troubleshoot and collaboratively resolve complex problems under tight time constraints
• Expertise in protein chromatography and tangential flow filtration
• Expertise with the AKTA platform and Unicorn software
• Experience writing regulatory documents as well as good oral and written communication skills
• Familiarity with process modeling techniques, statistical analysis, and DOE
• GMP experience. Familiarity with tech transfer to pilot and commercial manufacturing desired
• Team player and customer focused
• Supervisory experience desired
Job Complexity: The job is complex, requiring a thorough understanding of the biological and chemical properties of recombinant proteins, process design, and data analyses.
Supervision: Reports directly to a Principal Scientist / Associate Director but is expected to work independently on a day-to-day basis. Will supervise B.S./M..S./Ph.D scientists and engineers directly or in matrix
(Supervision required, level of independence) |
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Requirements/Qualifications:
Education: Education: Ph.D. in biochemistry, chemical/biochemical engineering, or related field.
Experience: 0-3 years of relevant experience for Scientist I; 3-7 years of relevant experience for Scientist II.
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| None Specified |
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